以分子伴侣为干预靶点成为治疗缺氧缺血性脑病的可能性?

C Hua, W Ju, H Jin, X Sun, G Zhao - 中国神经再生研究(英文版), 2017 - sjzsyj.com.cn
… are immediately degraded by the ubiquitin-proteasome system or by … The HSP70 family
includes HSC70 and inducible HSP70 in … in gene expression (Brucklacher et al., 2002), following

脑卒中诱导免疫抑制中的分子伴侣

H Qiao, Q Xu, Y Xu, Y Zhao, N He, J Tang… - 中国神经再生研究 …, 2023 - sjzsyj.com.cn
Hsp70 in the brain had better neurological performance after … the expression of Hsp70 in
ischemic regions of the brain by … Hsp70 can also exert neuroprotection through the ubiquitin-…

精神病学指征以外的锂: 一种新旧药物的转世

M Haupt, M Bähr, TR Doeppner - 中国神经再生研究(英文版), 2021 - sjzsyj.com.cn
… of HSP70 as a therapeutic target in IS has just been recognized in recent years after the …
on the behavioral outcome after transient global cerebral ischemia revealed an improved …

单羧酸转运体4 在缺血预处理保护缺血海马CA1 神经元中的作用

S Hong, JY Ahn, GS Cho, IH Kim, JH Cho… - 中国神经再生研究 …, 2015 - sjzsyj.com.cn
… (IPC) on MCT4 immunoreactivity after 5 minutes of transient cerebral ischemia in the gerbil.
… infarct zone of permanent focal ischemia at 120 hours after ischemia in the rat (Zhang et al., …

[PDF][PDF] 缺氧诱导因子-1 (HIF-1) 及其在水生动物中的研究进展

蔡秀红, 黄贻涛, 张子平, 王艺磊 - 农业生物技术学报, 2014 - journal05.magtech.org.cn
… by the proteasome following prolyl-hydroxylation and ubiquitination in … is available about
the gene expression in response to … Hsp70 and CHIP selectively mediate ubiquitination and …

神经元型一氧化氮合酶的神经生物学研究进展

CX Luo, DY Zhu - Neuroscience Bulletin, 2011 - Springer
… Regulation of nNOS expression relies largely on cAMP response element-binding
protein (CREB) activity, and nNOS activity is regulated by heat shock protein 90 (HSP90)/HSP70, …

[PDF][PDF] 自噬与神经系统疾病

杨小蕾, 冉希, 廖雪莲, 韩莉, 康焰 - 中华危重病急救医学, 2018 - cccm-em120.com
… 溶酶体内的HSP73 和 HSP70 再帮助底物转运入溶酶体内部,最终溶酶体内水解酶 将底物降解
,… of the ubiquitin proteasome system and autophagy lysosome system induced after traumatic …

自噬在抗肿瘤药物毒性中的作用与机制研究进展

陈剑, 曾艳, 高子正, 胡誉怀, 颜皓, 徐志飞, 罗沛华… - 药学进展, 2022 - pps.cpu.edu.cn
… protein 70,HSP70)和其他分子伴侣蛋白介导,与 溶酶体上的受体LAMP-2A 结合从而进入溶酶体
… 其一是Atg12 连接体系,在自 噬进程中泛素活化酶(ubiquitin-activating enzyme, E1)样酶Atg7 以…

[PDF][PDF] 肌萎缩侧索硬化症治疗药物研发进展

李栩琳, 杨婉琪, 王贵彬… - 中国药理学与毒理学杂志, 2018 - cjpt.magtechjournal.com
… 诱导神经元,肌肉细胞和胶质细胞中 HSP70/90的表达[49],加速突变… Glutamate transporter gene
expression in amyotrophic … in the SOD1G93A rat model of amyotrophic lateral sclerosis after